Pathogenesis of cupping of the optic disc

Pathogenesis of cupping of the optic disc.

Pathogenesis of cupping of the optic disc

Optic disc cupping (ODC) is a classical feature of chronic simple glaucoma. In attempts to explain the pathogenesis of ODC, a very large volume of literature has accumulated since its discovery over I 20 years ago, but the mechanism is still far from clear. The presence of ODC with no rise in intraocular pressure (IOP), first described by von Graefe (I857), has further contributed to the confus...

Colobomatous cupping of the optic disc.

Coloboma confined to the optic disc is a relatively rare condition (Steinberg, 1943), and has been described as unilateral in the majority of cases (Duke-Elder, I964; FranSois, I964). However, manifestation of the deformity may occur in the other eye (Hughes, 1947), and a number of bilateral cases have now been described. This paper records another bilateral case. A 35-year-old man was found to...

Clinical characteristics of nonglaucomatous optic disc cupping

Pathological optic disc cupping (ODC) is predominantly referred to as glaucoma; however, it is not only glaucoma that leads to pathological optic disc excavation. A number of other nonglaucomatous diseases also result in optic atrophy and excavation of the optic disc. Therefore, in the present study, the etiology of nonglaucomatous optic disc cupping (NGODC) was analyzed and differentiated from...

Optic disc cupping: four year follow-up from the WESDR.

Change in optic disc cupping was evaluated in a 4-year follow-up of a well defined cohort of people with diabetes mellitus. Cup-to-disc ratios were computed for both vertical and horizontal diameters of each eye at the baseline and 4-year follow-up examinations. Graders were masked as to the identity of participants and to the dates of the photographs. Increases of at least 0.1 between baseline...